Vincent H.J. van der Velden, PhD

Laboratory Specialist Medical Immunology
Laboratory Medical Immunology, Department of Immunology
Leukemia and Lymphoma Diagnostics (LLD) Research Group

v.h.j.vandervelden@erasmusmc.nl

Leukemia and Lymphoma Diagnostics (LLD) Research Group

The LLD group focusses on state-of-the-art diagnostics, diagnostic innovations, and translational research in hematological malignancies, with emphasis on acute myeloid leukemia and B-cell malignancies.

Our goals

  1. Improving diagnostics in patients with hematological malignancies by developing and implementing novel technologies, with emphasis on flowcytometric immunophenotyping and molecular technologies (particularly immunoglobulin and T-cell receptor gene rearrangements).
  2. Develop and evaluate sensitive methods to detect Minimal Residual Disease (MRD) and to evaluate which patients may benefit from intensification or reduction of therapy.
  3. Immune-monitoring of patients with hematological malignancies treated with novel immune-therapies (including antibodies and CAR-T cells) to identify parameters that may predict the efficiency such therapies.

Our projects

Some of our current projects include:

  • MRD4ALL (KIKA): together with the Princess Maxima Center (Utrecht) we evaluate whether genetic abnormalities, identified by Targeted-locus amplification, RNA-seq, or whole-genome sequencing, can be used for MRD analysis in children with acute lymphoblastic leukemia.
  • Immune-monitoring and MRD analysis in acute leukemia patients treated with the CD22 antibody-drug conjugate Inotuzumab (within international trial; with Princess Maxima Center).

Mechanism of action of Inotuzumab (CD22-calicheamicin antibody-drug conjugate used for the treatment of acute leukemia).

  • Immune-monitoring and MRD analysis in acute leukemia patients treated with the CD19xC3 bi-specific antibody blinatumomab (within international trial; with Department of Hematology, University of Brussels, University of Ghent).
  • EuroFlow (multiple European university medical centers): within this network we aim to develop novel tools for flowcytometric immunophenotypic analysis of hematological malignancies, including novel antibody panels for diagnosis and classification as well as software tools for database-supported analysis of flowcytometric data. Within EuroFlow, the LLD group particularly focusses on acute leukemia (BCP-ALL, AML).

Automated  database-supported  classification of acute leukemia.

Group members

  • Vincent van der Velden, group leader
  • Anne Bras, PhD student
  • Maaike de Bie, technician
  • Claudia Brandt-Hagens, technician
  • Selene Busio, technician
  • Jolanda Doekharan-van der Sluis, technician
  • Patricia Hoogeveen, technician
  • Stijn de Jong, technician
  • Romana Jugooa, technician
  • Jeroen te Marvelde, technician
  • Rianne Noordijk, technician
  • Sjoerd Oude Alink, technician
  • Gonnie Paulides, technician
  • Zara-Li van der Sande, technician
  • Charissa Wijnands

Selected Publications

(Check for all publications for Van der Velden VH in Pubmed)

  1. Hanekamp D, Denys B, Kaspers GJL, Te Marvelde JG, Schuurhuis GJ, De Haas V, De Moerloose B, de Bont ES, Zwaan CM, de Jong A, Depreter B, Lammens T, Philippé J,  Cloos J, van der Velden VHJ. Leukaemic stem cell load at diagnosis predicts the development of relapse in young acute myeloid leukaemia patients. Br J Haematol. 2018 Nov;183(3):512-516. doi: 10.1111/bjh.14991. Epub 2017 Oct 26. PubMed PMID: 29076143.
  2. Lhermitte L, Mejstrikova E, van der Sluijs-Gelling AJ, Grigore GE, Sedek L, Bras AE, Gaipa G, Sobral da Costa E, Novakova M, Sonneveld E, Buracchi C, de Sá Bacelar T, Te Marvelde JG, Trinquand A, Asnafi V, Szczepanski T, Matarraz S, Lopez A, Vidriales B, Bulsa J, Hrusak O, Kalina T, Lecrevisse Q, Martin Ayuso M, Brüggemann M, Verde J, Fernandez P, Burgos L, Paiva B, Pedreira CE, van Dongen JJM, Orfao A, van der Velden VHJ. Automated database-guided expert-supervised orientation for immunophenotypic diagnosis and classification of acute leukemia.  Leukemia. 2018 Apr;32(4):874-881. doi: 10.1038/leu.2017.313. Epub 2017 Nov 1. PubMed PMID: 29089646; PubMed Central PMCID: PMC5886046.
  3. Theunissen PMJ, van Zessen D, Stubbs AP, Faham M, Zwaan CM, van Dongen JJM, Van Der Velden VHJ. Antigen receptor sequencing of paired bone marrow samples shows homogeneous distribution of acute lymphoblastic leukemia subclones. Haematologica. 2017 Nov;102(11):1869-1877. doi: 10.3324/haematol.2017.171454. Epub 2017 Aug 31. PubMed PMID: 28860343; PubMed Central PMCID: PMC5664391.
  4. Theunissen PMJ, van den Branden A, Van Der Sluijs-Gelling A, De Haas V, Beishuizen A, van Dongen JJM, Van Der Velden VHJ. Understanding the reconstitution of the B-cell compartment in bone marrow and blood after treatment for B-cell precursor acute lymphoblastic leukaemia. Br J Haematol. 2017 Jul;178(2):267-278. doi: 10.1111/bjh.14685. Epub 2017 May 25. PubMed PMID: 28542787.
  5. Theunissen P, Mejstrikova E, Sedek L, van der Sluijs-Gelling AJ, Gaipa G, Bartels M, Sobral da Costa E, Kotrová M, Novakova M, Sonneveld E, Buracchi C, Bonaccorso P, Oliveira E, Te Marvelde JG, Szczepanski T, Lhermitte L, Hrusak O, Lecrevisse Q, Grigore GE, Froňková E, Trka J, Brüggemann M, Orfao A, van Dongen JJ, van der Velden VH; EuroFlow Consortium. Standardized flow cytometry for highly sensitive MRD measurements in B-cell acute lymphoblastic leukemia. Blood.  2017 Jan 19;129(3):347-357. doi: 10.1182/blood-2016-07-726307. Epub 2016 Nov 30.  PubMed PMID: 27903527; PubMed Central PMCID: PMC5291958.
  6. van der Velden VH, de Launaij D, de Vries JF, de Haas V, Sonneveld E, Voerman JS, de Bie M, Revesz T, Avigad S, Yeoh AE, Swagemakers SM, Eckert C, Pieters R, van Dongen JJ. New cellular markers at diagnosis are associated with isolated central nervous system relapse in paediatric B-cell precursor acute lymphoblastic leukaemia. Br J Haematol. 2016 Mar;172(5):769-81. doi: 10.1111/bjh.13887. Epub 2015 Dec 21. PubMed PMID: 26898195.
  7. van der Velden VH, Hoogeveen PG, de Ridder D, Schindler-van der Struijk M, van Zelm MC, Sanders M, Karsch D, Beverloo HB, Lam K, Orfao A, Lugtenburg PJ, Böttcher S, van Dongen JJ, Langerak AW, Kappers-Klunne M, van Lom K. B-cell prolymphocytic leukemia: a specific subgroup of mantle cell lymphoma. Blood. 2014 Jul 17;124(3):412-9. doi: 10.1182/blood-2013-10-533869. Epub 2014 Jun 2. PubMed PMID: 24891323.
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